DNA that repairs DNA: discovering PDRN and Nucleotide Hydrolysates
PDRN (polydeoxyribonucleotide) is a polymer composed of DNA fragments, derived primarily from salmon sperm cells—particularly salmon trout or chum salmon—which are naturally rich in nucleic acids. This extraction process is sustainable and does not involve the death of the animal, an important ethical choice also in the cosmetics field.
Purified and sterilized to a 95% pure powder, PDRN is highly biocompatible and can penetrate skin tissue thanks to its low molecular weight. At the cellular level, this active ingredient acts directly, stimulating skin regeneration, collagen and elastin production, damaged tissue repair, and even healing microlesions.
Its effects? Visibly firmer, more radiant, and hydrated skin. Among the most appreciated actions in the aesthetic field are: wrinkle reduction, dark spot reduction, plumping effect, post-treatment healing support, and even effectiveness in the treatment of female alopecia.
An active ingredient that doesn't simply mask blemishes, but works at the root of the problem, deeply regenerating the skin.
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DNA and RNA hydrolysates: intelligent and ultra-high-performance active ingredients
DNA and RNA hydrolysates are low molecular weight nucleotides, obtained from the hydrolysis of nucleic acids, and are therefore capable of penetrating deeply into the epidermis, where they act rapidly and in a targeted manner, in synergy with PDRN. On the one hand, they function as transepidermal carriers: they transport other active ingredients into the cell, facilitating their absorption and enhancing their effects; on the other, they act directly on the skin: they stimulate collagen production, deeply hydrate by binding water molecules, and protect cells from oxidative stress.
SkinGenesis: the treatment that awakens the skin's regenerative potential
After exploring the science revolutionizing regenerative cosmetics, it's time to explore the treatment that fully embodies this evolution: the SkinGenesis line. A true cellular regeneration accelerator, designed to deliver visible results from the first session. Designed for aestheticians who want to stand out, SkinGenesis integrates the power of PDRN, DNA and RNA hydrolysates, and next-generation anti-aging active ingredients in a single solution.
The result? Skin that awakens, restructures, and regains its natural radiance.
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PDRN Cell Regenerative: The New Frontier of Dermatological Regeneration
PDRN Cell Regenerative from the SkinGenesis line is a comprehensive and intensive anti-aging treatment that retrains cells to perform their innate function. After just the first application, skin appears more toned, elastic, and plump, with wrinkles visibly smoothed.
And in the medium to long term? We're seeing a true reset of the cellular functions involved in skin longevity.
The heart of the treatment is a synergy of high-profile active ingredients:
- PDRN: repairing and regenerating, it stimulates fibroblasts and promotes the endogenous production of collagen, elastin, and hyaluronic acid, combating aging, inflammation, and discoloration.
- DNA & RNA hydrolysates: powerful low-molecular-weight fractions penetrate deeply, delivering active ingredients and promoting hydration, antioxidant protection, and structural renewal of the dermis.
- Full-spectrum hyaluronic acid: acts on multiple levels of the skin, ensuring an immediate lifting effect, firmness, smoothness, and firmness.
- Trehalose: protects and stabilizes cellular structures even in stressful conditions, counteracting environmental damage and free radicals.
- Allantoin: soothing, re-epithelializing, and antioxidant, it stimulates cell renewal and strengthens the skin barrier.
This advanced formula does more than just improve the skin's external appearance: it activates deep regeneration processes, supports cellular longevity, and transforms the treatment into a visible and tangible wellness experience.
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The Synergy of PDRN and Nanospheres to Enhance Transdermal Delivery of Active Ingredients
The SkinGenesis Regenerative Cosmetics project combines the cosmetic application of PDRN with the use of the HydraPen H3 device, with a Nanosphere cartridge or needles for needling treatments.
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HydraPen H3
HydraPen H3 is a professional electric cosmetic pen designed to improve the health and appearance of skin.
The disposable Nanosphere cartridges, thanks to their multidirectional and multifunctional mechanical rotation, are capable of producing transdermal delivery of active ingredients that previously unattainable with instruments designed to date. This technology is specifically designed to produce dermal stimulation that increases the already high and autonomous transdermal delivery capacity of PDRN.
Through this specific mechanical action, the nanomolecules are able to more effectively penetrate the most superficial layers of the skin and penetrate deep into the dermis, where they activate cellular communication and perform their important functions.
The result achieved with its use is an immediate improvement in the skin's appearance and a visible reduction in blemishes and signs of aging.
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Nanosphere or 12-pin needle cartridges
The Hydra Pen H3 can be used with either a Nanosphere or 12-pin needle cartridge.
Nanospheres are the result of enhancing the delivery tools currently available to the modern professional. Through their movements, which cannot be reproduced with traditional facial massage techniques, Nanospheres ensure the penetration of active ingredients into the deepest layers of the skin.
The needles of SkinSystem's 12-pin cartridges are designed to offer targeted, high-performance treatments, ideal for stimulating skin regeneration and improving the absorption of active ingredients.
The 12-pin configuration allows for controlled and uniform penetration, promoting targeted skin stimulation without causing trauma.
This concludes our journey through SkinSystem's Regenerative Cosmetics, a journey that led us to discover the new SkinGenesis technology based on PDRN and DNA and RNA hydrolysates, followed by a brief refresher on exosome-based vials, before moving on to the Advanced Cosmetics of Hydrolyzed Collagen and Acid-based peels.
Why all these stops? Because we want to emphasize once again how important it is for a beauty professional to be able to navigate a wide range of techniques, knowing them thoroughly and integrating them into highly specialized and personalized protocols for each client to always guarantee the best possible results.
Advanced beauty today no longer limits itself to masking the signs of aging: it reprograms them, slows them down, and prevents them. Understanding and integrating the right regenerative active ingredients—like PDRN and exosomes—means building intelligent, customized protocols that respond to the increasingly widespread need for authentic, profound, and lasting beauty.
